Serum Proteins in Myasthenia Gravis

Peter Kornfeld, MD
JAMA. 1964;190(5):463. doi:10.1001/jama.1964.03070180061010.
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RECENT INVESTIGATION in myasthenia gravis has suggested that an auto-immune mechanism may be operative in this disease.1-3 The literature also contains many speculations dealing with the relation of thymus abnormality, a frequent occurrence in myasthenia gravis, and serum γ-globulin variations.4,5 Finally, there is conflicting data in the foreign literature regarding the behavior of 7-globulins in various neuromuscular disorders.6,7 It was decided therefore to screen the serums of 61 patients with myasthenia gravis.

In selection of 61 cases of myasthenia gravis for this study, care was taken to exclude all those with associated diseases which might affect serum proteins. The selected cases included all the clinical classifications of myasthenia gravis strips were removed and dried in an oven at 70 C for 20 minutes. Amidoblack was used for staining. The protein patterns were separated into albumin, α1-, α2-, β-, and γ-globulins. Quantitative determinations were made of


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