Time-Dose Considerations May Affect Radiation Myelopathy

JAMA. 1964;190(3):41. doi:10.1001/jama.1964.03070160099050.
Text Size: A A A
Published online


Reduced fractionation schedules in radiotherapy appear to increase the possibility of radiation myelopathy, two investigators at the Medical Research Center, Brookhaven National Laboratory, Upton, NY, reported to the seventh Symposium Neuroradiologicum.

Harold L. Atkins, MD, and Patricia Tretter, MD, reviewed 14 patients at the Columbia-Presbyterian Medical Center who developed necrosis of the spinal cord as a result of radiation therapy.

All but one were treated with unconventional fractionation techniques. The number of treatments varied from one to 26 and the probable cord dose from 830 to 5,200 rads (r). Half of the patients were treated for carcinoma of the breast; three had lung cancer. The remaining patients had cancer of the tongue and esophagus, cylindroma of the trachea, and Hodgkin's disease.

Treatment Was Varied  Four patients with cancer of the breast were treated as part of an experimental series and received 2,380 r in two divided doses a week apart.


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.