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Balance Between Active And Inactive Insulin in Blood May Be Factor in Diabetes

JAMA. 1964;189(7):27-28. doi:10.1001/jama.1964.03070070073043.
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Healthy individuals appear to regulate insulin activity in the body by maintaining a balance between biologically active and relatively inactive forms of insulin, the fifth congress of the International Diabetes Federation was told.

Harry N. Antoniades, PhD, told the July meeting at Toronto that transformation of insulin from its active or "free" form into its rela[ill]ely inactive or "bound" form, and the activation of bound insulin under [ill]tain circumstances, appear to take place at the tissue level. The rate of insulin activation or inactivation depends upon the metabolic state of the individual.

"Any factor affecting the rates at which insulin is activated or inactivated could also influence insulin activity in the body," Antoniades added. "It is suggested that in some types of diabetes, hyperglycemia may be associated with abnormalities resulting in altered rates of transformation."

Antoniades, 1962 winner of the Lilly Award of the American Diabetes Association, is senior investigator


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