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Thalassemia Minor and Pelger-Huët Anomaly

Paul G. Hattersley, MD; Norman R. Eade, MD
JAMA. 1964;189(7):588. doi:10.1001/jama.1964.03070070060028.
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To the Editor:—  Thalassemia minor is a common familial anomaly in many parts of the world; Pelger-Huët anomaly is less common. Both are inherited as autosomal intermediates, the homozygote being affected seriously,1 while the heterozygote may be entirely healthy. Following is a brief report of a patient having both anomalies, and a family history suggesting genetic segregation.A 30-year-old white male stated that he had been "tired most of the time" for at least ten years. Past history revealed no serious illnesses, and findings of the physical examination were normal. There was low-grade anemia (hemoglobin 12.2 gm%) which was microcytic (mean corpuscular volume 65 cu μ) with low-grade hypochromia (mean corpuscular hemoglobin concentration 29.5%). Target cells and basophilic stippling were observed on the blood smears. Erythrocyte fragility in hypotonic sodium chloride solution was moderately decreased (75% hemolysis in 0.35% sodium chloride; normal: over 90%). Serum iron was normal 105μg%).


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