Acanthosis Nigricans With Lupoid Hepatitis

Denny L. Tuffanelli, MD
JAMA. 1964;189(7):584-585. doi:10.1001/jama.1964.03070070056020.
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ACANTHOSIS NIGRICANS was first described by Pollitzer in 1891 as a symmetrical eruption usually involving the axillae, neck, and knuckles and characterized by hyperpigmented, soft, verrucous folds of skin. Winkelmann1 stated that acanthosis nigricans occurs in patients with endocrine diseases in whom obesity is not a constant factor. To the knowledge of the present author, the association of acanthosis with lupoid hepatitis has not been reported. This papers reports the apparent combination of these diseases.

Report of a Case  A 17-year-old female Mexican student was first seen at the Los Angeles County Hospital in January, 1963. She had entered the United States six months previously and since that time had developed jaundice, malaise, and oligomenorrhea. She also had frontal headaches associated with dizziness. One year earlier she had an episode of arthritis of the right knee. There was no history of fever, polyarthritis, alopecia, Raynaud's phenomenon, or pleurisy.Upon


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