Published Online: May 20, 2012. doi:10.1001/jama.2012.5535
Author Contributions: Dr Rahman had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Mishra and Davies were joint first authors.
Study concept and design: H. Davies, Lee, R.J.O. Davies, Rahman.
Acquisition of data: H. Davies, Mishra, Wrightson, Stanton, Guhan, C.W.H. Davies, Grayez, Harrison, Prasad, Crosthwaite, Rahman.
Analysis and interpretation of data: H. Davies, Mishra, Kahan, Wrightson, Lee, Miller, Rahman.
Drafting of the manuscript: H. Davies, Mishra, Kahan, Wrightson, Grayez, Crosthwaite, Miller, Rahman.
Critical revision of the manuscript for important intellectual content: H. Davies, Mishra, Kahan, Stanton, Guhan, C.W.H. Davies, Grayez, Harrison, Prasad, Crosthwaite, Lee, Miller, Rahman.
Statistical analysis: Mishra, Kahan, Rahman.
Obtained funding: H. Davies, R.J.O. Davies, Lee.
Administrative, technical, or material support: H. Davies, Mishra, Wrightson, Stanton, Grayez, Prasad, Crosthwaite, Rahman.
Study supervision: R.J.O. Davies, Rahman.
Conflict of Interest Disclosure: All authors completed and submitted the ICMJE Form for Disclosure and Potential Conflicts of Interest. Dr Wrightson reported that he has received honoraria, grant support to attend a conference from Boehringer Ingelheim. Dr Guhan reported receiving support from Medico for expert testimony; having served on the speakers' bureau for AstraZeneca, GlaxoSmithKline, and Chiesi; and receiving support for conference attendance from Chiesi and GlaxoSmithKline. Dr C. Davies reported serving on the speakers' bureau for AstraZeneca. Dr Lee reported receiving honoraria from CareFusion and Sequana Medical as an advisory board member. Dr Miller reported receiving support for lectures on HIV infection from Merck and Gilead. Dr Rahman reported that he acts as a consultant to Rocket Medical for device development. No other conflicts of interest were reported.
Funding/Support:This study was supported with an unrestricted education grant from the British Lung Foundation and the Robert Luff Foundation, London, England The study was sponsored by the University of Oxford. The IPCs and drainage bottles were provided by Rocket Medical, Washington, England.
Role of the Sponsors: The sponsors did not participate in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Protocol: Available from the corresponding author.
Additional Contributions:We thank Ian White, PhD, MRC Biostatistics Unit, Cambridge, England, and Patrick Royston, PhD, MRC Clinical Trials Unit, London, England, for helpful discussions regarding statistical analysis, Sue Meakin, RN, Great Western Hospital, Swindon, Nicky Bateman, RN, University of North Tees, North Tees, and Pauline Spence, RN, James Cook University Hospital, South Tees, and Jack Quaddy, BA, Oxford Respiratory Trials Unit, for data acquisition, and all at the Oxford Respiratory Trials Unit, none of whom received compensation.