Marked differences may be apparent in the urinary growth hormone levels of patients with short stature of different etiologies, two investigators from the Albert Einstein College of Medicine, Bronx, NY, have discovered.
Jack Geller, MD, and Arthur Loh, MA, reporting at the 46th meeting of the Endocrine Society in San Francisco in June, suggested that the differences in urinary growth hormone levels may reflect the etiology of dedevelopmental retardation.
Using immuno-assay techniques the investigators measured growth hormone levels in extracts of urine from persons of normal size and from patients with short stature due to: ( 1 ) constitutionally retarded development characterized by proportional retardation in height age and bone age; (2) primordial dwarfism; and (3) primary bone disorders.
Normal values of growth hormone in 24-hour urine extracts were found to range from 10 to 125μgm. In 13 of 15 short stature patients with constitutionally retarded development, urinary growth hormone levels were