Clinical Aspects of Iodine Metabolism

Solomon A. Berson, MD
JAMA. 1964;189(2):169. doi:10.1001/jama.1964.03070020097045.
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This book is directed principally to the student and the clinical specialist rather than the scholar. The account is patient and expository; quantitative aspects of main pathways of iodine metabolism are emphasized with detailed descriptions of calculations, presentation of data, and frequent repetition. The authors rightly stress thyroidal clearance of plasma iodide 131 in preference to simple thyroidal uptake values as a measure of thyroidal activity. The product of thyroidal clearance and the plasma concentration of iodide 127 (determined indirectly from simultaneous measurement of urinary specific activity and plasma iodide 131) provides the best estimate of the amount of iodine accumulated by the thyroid, but, as the authors correctly observe, thyroidal iodide 131 clearance adjusts only slowly to alterations in iodine intake.

Intrathyroidal synthesis, thyroidal secretion and peripheral metabolism of thyroid hormones are discussed thoroughly with due consideration of the many disturbances of these functions encountered in various disease states.


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