Total Gastrectomy May Be a Life Saver For Patient with Ulcerogenic Tumor of Pancreas

JAMA. 1964;189(1):A32-A33. doi:10.1001/jama.1964.03070010092047.
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Total gastrectomy is the most effective treatment for patients suffering from ulcer associated with non-beta islet cell tumors of the pancreas, (Zollinger-Ellison syndrome), according to Robert M. Zollinger, MD, of the department of surgery, Ohio State University Hospitals.

Zollinger, in presenting a review of data obtained from studies of more than 250 patients, said that ulcerogenic tumors of the pancreas are relatively uncommon, but may be implicated in about 10% of problem ulcers.

In diagnosing the problem, he said, enteritis plays a major role in the clinical syndrome. "While 90% of the patients tend to develop signs and symptoms of a severe ulcer diathesis, enteritis may be the only complaint in 10%."

He said studies have shown that enteritis is the initial complaint in about one of every five cases involving the Zollinger-Ellison syndrome, and that "enteritis of varying severity occurs in 40% of all patients having an ulcerogenic tumor


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