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Fluoride, Calcium Salts, Hormones Tried in Osteoporosis Therapy

JAMA. 1964;188(7):27-28. doi:10.1001/jama.1964.03060330089044.
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A combination of agents may provide the most effective means of treating osteoporosis, inasmuch as available drugs fall short of the ideal, according to Daniel S. Bernstein, MD.

The ideal agent, Bernstein said, is one which would reduce bone resorption and stimulate bone formation without compromising either the functional quality of bone tissue or calcium homeostasis, and which would, in addition, strengthen the existing crystalline structure of the bone.

Bernstein, an instructor in medicine at Harvard Medical School and a senior associate in medicine at Peter Bent Brigham Hospital, Boston, presented his views on osteoporosis therapy at a symposium on "Anabolism and Catabolism in Health and Disease" sponsored by the Department of Medicine of Hahnemann Medical College and Hospital in Philadelphia May 4 and 5. Co-outhors of the paper were David J. Baylink, MD, and Charles D. Guri, MD, both research fellows at Harvard Medical School and assistants in medicine


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