A CASE was recently observed in which measles had onset one week following chickenpox. Surrounding each chickenpox lesion was a zone of normal-appearing skin which never became involved with measles rash. These findings suggested the natural occurrence of a local viral interference phenomenon.
Report of a Case
A 7-year-old boy developed a febrile illness characterized by brightly flushed cheeks and slight malaise, which was followed three days later, on March 31, 1963, by onset of a vesicular rash characteristic of chickenpox. The rash spread maximally within two days and gradually faded in association with recovery from illness.On April 6 febrile illness recurred, this time with considerable prostration, irritation of the eyes, and a dry hacking cough. On April 7 a rash appeared which, by the next day, was typical of measles. At this time (April 8) the crusted healing lesions of chickenpox were surrounded by zones of apparently normal