We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Clinical Notes |

Hyperlipemia Following Sulfonylurea Therapy in Young Diabetics

Joseph C. Shipp, MD; Francis C. Wood Jr., MD; Alexander Marble, MD
JAMA. 1964;188(5):468-470. doi:10.1001/jama.1964.03060310068018.
Text Size: A A A
Published online


PATIENTS with untreated diabetes mellitus often demonstrate some elevations of plasma lipids. The increased blood concentrations of free fatty acids (FFA), triglycerides, cholesterol, and phospholipids usually return to normal with treatment which improves glucose utilization.

This report describes the occurrence of severe hyperlipemia associated with lipemia retinalis and xanthomatosis in certain diabetic patients treated with sulfonylurea compounds. In each instance, the control of the patient's hyperglycemia by the sulfonylurea was inadequate. These observations emphasize the importance of adequate follow-up of carbohydrate metabolism in patients treated with oral hypoglycemic agents.

Methods  Venous blood was drawn while the patient was in the fasting state unless otherwise noted. Blood glucose was determined by the method of Somogyi,1 total lipids by the method of Folch,2 FFA by the method of Dole,3 cholesterol by the method of Abell,4 and phospholipids by the method of Sperry.5 Patients were hospitalized during the


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.