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JAMA. 1964;188(1):70. doi:10.1001/jama.1964.03060270076019.
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The clinician is faced with a bewildering number of diuretic drugs. Frequent additions of new agents are testimony to the continuing search for the ideal diuretic compound. Recognizing that a "perfect" diuretic drug is not available, the physician must inquire if one of the current potent agents is superior to others. Swartz and associates1 recently reported five years' experience with the evaluation of the newer diuretic agents. Twelve diuretic drugs, including thiazides, chlorthalidone, quinethazone, and meralluride diuretics, were studied in normal subjects and in patients with congestive failure. Comparison of drug efficacy is particularly difficult to determine in the edematous patient, because the severity of the disease processes causing edema is variable. These investigators, therefore, studied the physiological action of diuretic drugs in normal subjects to evaluate electrolyte changes effected by diuretic agents. The combination of a mercurial and a thiazide caused significantly greater natruretic effect than any other


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