Cerebral Circulation Tends To Resist Alterations Due To Drug Administration

JAMA. 1964;187(13):34-35. doi:10.1001/jama.1964.03060260082046.
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Cerebral circulation is "probably less affected by drugs than that of any other organ," Louis Sokoloff, MD, of the Section on Cerebral Metabolism of the National Institute of Mental Health, told the Hahnemann Medical College Symposium on Shock and Hypotension, March 18-21 in Philadelphia. "Drugs influence the cerebral circulation by altering the physiological mechanisms which normally regulate it," Sokoloff said, but the autoregulatory nature of cerebral circulation tends to resist such change.

"The circulation of the brain, like its metabolism, enjoys a considerable measure of autonomy compared to these functions in other areas of the body. The physiological mechanisms controlling and regulating the cerebral circulation differ distinctly from those of most other vascular beds. They reflect a high order of adaptation to the special features of cerebral metabolism and function and serve to preserve the brain to a considerable extent from the effects of stresses encountered by the body as


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