Vasoconstricting Drugs Raise Blood Pressure But Do Not Improve Tissue Metabolism

JAMA. 1964;187(13):33-34. doi:10.1001/jama.1964.03060260081045.
Text Size: A A A
Published online


Prolonged use of vasoconstrictor agents in hemorrhagic shock is detrimental," William R. Drucker, MD, of the Department of Surgery at Western Reserve University, told the Hahnemann Medical College Symposium on Shock and Hypotension, March 18-21 in Philadelphia. "However, there may be a selective beneficial role for vasoconstrictor agents in hemorrhagic hypotension which is not related to their ability to restore a normal blood pressure," Drucker said.

The ideal treatment of severe hemorragic shock is replacement of the lost blood, but occasionally blood is not immediately available. Drucker suggested that many physicians have been reluctant under such circumstances to use colloid solutions as substitutes "because they fear that erythrocyte-free solutions will restore volume at the expense of oxygencarrying capacity in a situation where the primary objective is the prevention of tissue anoxia."

Consequently, Drucker and Hastings K. Wright, MD, sought to discover whether it would be preferable to use vasoconstrictor drugs


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.