0
LINCOLN CONTRIBUTIONS |

Skeletal Manifestations in the Marfan Syndrome

Harvey I. Wilner, MD; Nathaniel Finby, MD
JAMA. 1964;187(7):490-495. doi:10.1001/jama.1964.03060200022003.
Text Size: A A A
Published online

THE MARFAN SYNDROME is a heritable disease of connective tissue which involves many organ systems but has its chief clinical significance in abnormalities of the ocular, cardiovascular, and skeletal structures. The fully developed syndrome is readily recognized clinically in a tall patient with arachnodactyly who exhibits bilateral lens dislocation and dissecting aneurysm of the aorta. It is important to note, however, that the basic abnormality is generalized in the connective tissue and is not a congenital malformation of viscera. Therefore, the incidence of clinically detectable malformations will increase with age, and clinical abnormality may not be evident in every individual with the syndrome.

Accurate diagnosis is extremely difficult, especially without the full spectrum of clinical abnormality. Although more than 400 cases have been reported in the literature as examples of the Marfan syndrome, fewer than 10% of these are documented with pathological study1,2; the remainder have usually been diagnosed

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();