The neurosciences, neuroanesthesia in particular, have progressed substantially in the last decade. In the fifth edition of the well-established and highly respected Cottrell and Young's Neuroanesthesia, James Cottrell, William Young, and 23 new authors have provided scientists, students, and clinicians with a comprehensive review of contemporary neuroanesthesia. The editors have observed in their preface to the fifth edition that "[i]nformation flows from basic scientists to laboratory animal researchers to clinical investigators to scientific journals to clinical textbooks, and finally, to clinicians." In recognition of this flow, the editors emphasize clinical application in this edition, but the book also is intended to be useful to scientists, clinical investigators, journal editors, and basic clinicians. This textbook is not about algorithms; rather, it is about a rigorous review of the principles of the science, anatomy, pathophysiology, investigations, and interventions that represent the core of contemporary neurosurgical anesthesia.