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Clinical Notes |

Hematopoietic Stimulating Effect of a Cerebellar Hemangioblastoma

George J. Race, MD; James W. Finney, MS; John T. Mallams, MD; George A. Balla, MD
JAMA. 1964;187(2):150-151. doi:10.1001/jama.1964.03060150074027.
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THE EFFECT OF erythropoietin on hemoglobin concentration and other blood factors has been studied extensively.1-5 Erythropoietin is a plasma factor, characterized as a nondialyzable, nonultrafiltrable, relatively heat-stable glycoprotein which is not inactivated by changes in pH ranging from 3 to 10; it migrates electrophoretically with the α2-globulin and has a molecular weight of about 28,000. The site of its production has been postulated to be from renal tubular epithelium or vascular endothelium. Its production has been reported occasionally associated with carcinoma of the kidney, cystic disease of the kidney, hydronephrosis, nephrotic syndrome, leiomyomas of the uterus, and cerebellar hemangioblastomas.6-11

An additional case of hematopoietic stimulating effect of a cerebellar hemangioblastoma is reported here.

Report of a Case  The patient was a 62-year-old white male who entered the hospital complaining of headaches, nausea, and vomiting. Physical and neurological examination indicated a cerebellar ataxia. By means of ventriculograms,


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