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The Effect of Corticotropin on the Antral Phase of Gastric Secretion

Demetre M. Nicoloff, MD; E. T. Peter, MD; Raymond C. Doberneck, MD; Nelson H. Stone, MD; Owen H. Wangensteen, MD
JAMA. 1963;186(11):1006-1007. doi:10.1001/jama.1963.63710110013010d.
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IN RECENT YEARS there has been increasing interest in the hormonal aspects of peptic ulcer. Numerous reports of peptic ulcer associated with polyendocrine disease have appeared in the literature.1,2 In addition, the availability of various purified hormones for administration to patients has been accompanied by case reports of peptic ulcer reactivation or formation during their administration. The hormones most frequently associated with peptic ulceration are cortisone and corticotropin. Since these hormones are available in a pure state, it is possible to determine their effect on various body functions in both the experimental animal and the patient. Case reports of peptic ulcer formation in patients receiving corticotropin or cortisone would seem to support the concept that stress and anxiety play an important role in the development of acute and chronic peptic ulcers.3-5 The exact mechanisms that are responsible for this relationship are poorly understood. Whether the peptic ulcers


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