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Administration of Fluorouracil

R. J. Reitemeier, MD; Charles G. Moertel, MD
JAMA. 1963;186(10):958-959. doi:10.1001/jama.1963.03710100096027.
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To the Editor:  —This letter is written to challenge the conclusions drawn by Dr. Lemon and associates in their article "Decreased Intoxication by Fluorouracil When Slowly Administered in Glucose" (JAMA185:1012 [Sept 28] 1963).Since acceptance of the conclusions of these authors could lead to widespread "office practice" use of this method of treatment, we felt it important that a negative view of this means of therapy be presented to your readers.Lemon and associates have implied that the slow administration of fluorouracil in glucose is comparable in therapeutic effectiveness to the more commonly employed rapid injection method. Their comments are based on their results in treatment of patients with a variety of neoplasms. In many of these patients the results are invalidated for comparative purposes by simultaneous antineoplastic therapy with radiation, hormones, or fluorouracil administered orally as well as intravenously. They compare these results of the slow intravenous

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