0
Articles |

Brain Damage Due to Penicillin

Sheldon B. Cohen, MD
JAMA. 1963;186(10):899-902. doi:10.1001/jama.1963.03710100037008.
Text Size: A A A
Published online

Two young adults suffered anaphylactic shock after administration of penicillin. One patient received an intramuscular injection while the other ingested a tablet. Upon recovery from shock, signs and symptoms of an acute brain syndrome, including disorientation and confusion, were present. This was followed by a persistent chronic brain syndrome. Nine months after the episode of shock, one patient showed moderate intellectual impairment with constriction of interests and confabulation. The other patient, 15 months after being in shock, was severely impaired with disorientation, very poor memory, and was unable to adequately take care of her home or child. Other psychiatric disturbances due to penicillin do not generally have such serious sequelae. It seems quite probable that many other patients who recover from anaphylactic shock resulting from penicillin suffer some degree of brain damage due to

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();