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JAMA. 1940;114(23):2275-2279. doi:10.1001/jama.1940.02810230005002.
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Medical literature has considered instances of peripheral nerve involvement occurring in the course of specific diseases. Yet the concept of neuropathy due to a defective blood supply has not been sufficiently stressed.1 Recent experience in the wards of Lakeside Hospital with ischemic neuropathy has prompted us to assemble clinical examples which have occurred in a variety of diseases and to group them together under one heading.

ANATOMY  The standard textbooks of anatomy and histology give but brief mention to the vascular supply of peripheral nerves. Ramage2 observed that, in the nerve trunks, cords and peripheral nerves of the upper extremity, circulation is maintained through several nutrient arteries. His work substantiates the theory laid down by Quénu and Lejars3 that the blood supply of a peripheral nerve does not come from a single arterial branch but always comes from multiple sources.Buitink4 studied the blood supply of


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