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OVARIAN HORMONES AND FEMALE GENITAL CANCER

EDGAR ALLEN, Ph.D.
JAMA. 1940;114(21):2107-2114. doi:10.1001/jama.1940.62810210010012a.
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This paper does not attempt to summarize even the most recent work in this field. Instead, it merely outlines the development of my own point of view on the subject from the early work on the follicular hormone in which normal reactions were reproduced to work of more recent date indicating a possible role of this hormone in mammary and uterine cancer. Since the early work with Dr. Doisy on this hormone was done in St. Louis at Washington University School of Medicine, it means a great deal to me now1 to be able to present some more recent studies which have led to the experimental production of genital cancer.

I intend first to summarize briefly some of the principal results obtained in studies of animal reactions to ovarian hormones, especially estrogenic hormone, emphasizing above all its effect of producing growth in the female genital organs, for it seems

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