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DELAYED CUTANEOUS REACTION TO INTRADERMAL INJECTION OF BRUCELLERGEN IN BRUCELLOSIS

L. E. January, M.D.; James A. Greene, M.D.
JAMA. 1940;114(6):486-487. doi:10.1001/jama.1940.62810060001008.
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The cutaneous reaction following the intradermal injection of brucellergen is one of the diagnostic aids in brucellosis. The reaction, when positive, begins within twenty-four to thirty-six hours after injection and persists for more than forty-eight hours. The test is positive if, in addition to an area of erythema around the site of injection, there is also edema or induration which measures from 0.5 to 0.75 cm. or more in diameter. A delayed reaction, that is, one which does not begin until forty-eight hours or more after injection, is rare. It is for this reason that we are reporting a case in which the cutaneous reaction did not appear until the fourth day after the injection of brucellergen.

REPORT OF CASE  A farmer aged 43 entered the University Hospital July 10, 1938, because of headache, pain in the legs and fever. He had always enjoyed good health until December 1937, when

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