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Harold S. Schiro, M.D.
JAMA. 1940;114(3):272. doi:10.1001/jama.1940.02810030072027.
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To the Editor:—  In The Journal, Dec. 16, 1939, page 2229, an excellent example of "bromo-seltzer" poisoning is recorded by Dr. Alan Leslie, of New York. My purpose in this communication is to call attention to the incompleteness of its title "Acetanilid Poisoning" by emphasizing the role of bromides in poisoning by bromo-seltzer and other proprietary "pain killers."According to The Journal of Dec. 29, 1906, page 2138, as quoted in "Patent and Proprietary Medicines" by J. P. Street (published by the American Medical Association in 1917) the formula for bromo-seltzer contained in each dose potassium bromide 7 grains (0.45 Gm.) and acetanilid 3 grains (0.2 Gm.). In what way the present formula may have been changed I cannot say, but sufficient bromide was present in the drug one year ago to induce poisoning of two patients seen at the Cincinnati General Hospital.From the large doses of bromo-seltzer taken


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