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JAMA. 1939;113(24):2124-2128. doi:10.1001/jama.1939.02800490020005.
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The numerous claims and conflicting reports concerning treatment with male sex hormone make it desirable to define its use more precisely.

The testis consists essentially of two parts: (1) the seminiferous tubules, the most important function of which is to produce spermatozoa, and (2) the interstitial cells of Leydig, the most important function of which is to produce male sex hormone.1 What relationship, if any, exists between these two structures is unknown. On the production of the male sex hormone depends the development of secondary sex characteristics, namely the growth of the penis, scrotum, prostate, seminal vesicles, epididymis, vas deferens, body hair, beard, pitch of the voice and, to some extent, skeletal growth, including the contour of the body. Observations of the last few years have demonstrated conclusively that a delicate balance exists between the anterior lobe of the pituitary and the testis.2 The pituitary apparently stimulates the


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