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November 4, 1939, Vol 113, No. 19 >
Other Articles | November 4, 1939

SEROLOGIC DISCREPANCIES IN SYPHILIS:  THE POSITIVE HINTON-NEGATIVE WASSERMANN PROBLEM

MARSHALL CRAWFORD, M.D.; LEON F. RAY, M.D.
JAMA. 1939;113(19):1715-1720. doi:10.1001/jama.1939.02800440019006.
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The occurrence of a positive Hinton with a negative Wassermann reaction in patients with late syphilis gives rise to delicate problems of diagnosis as well as to the question of activity in old cases and the advisability of further treatment. The first technic of the Hinton test1 was adopted for routine use at the Massachusetts General Hospital in 1929. The present method,2 which is comparable to the Eagle, Kahn, Kline and Kolmer tests as to specificity and surpasses them in sensitivity,3 is similar in principle to the Eagle, Kahn and Kline tests. When the Hinton test was first used at the Massachusetts General Hospital it was applied to all bloods in conjunction with the Wassermann test. The technic of the latter test is a modification of the standard Wassermann test.4 A general agreement between the two tests led to the practice of omitting the Wassermann test

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