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THE ONE HOUR-TWO DOSE DEXTROSE TOLERANCE TEST (EXTON-ROSE PROCEDURE):  DIAGNOSTIC SIGNIFICANCE

MORGAN W. MATTHEWS, M.D.; THOMAS B. MAGATH, M.D.; JOSEPH BERKSON, M.D.; Robert P. Gage
JAMA. 1939;113(17):1531-1537. doi:10.1001/jama.1939.02800420005002.
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The present study is a part of a survey1 of dextrose tolerance tests of various types used in the Mayo Clinic between Nov. 1, 1935, and June 30, 1938, inclusive. The present report is confined to the analysis of results obtained with the one hour-two dose test introduced in 1931 by Exton and Rose.2 A criterion for interpreting this test is presented which in our experience has given fewer doubtful laboratory diagnoses than could be obtained by other criteria applied in this test, or by any criteria applicable in other oral tests for dextrose tolerance.

Following the discovery of chemical procedures by which the presence or absence of sugar in the urine can be accurately determined, it was noted that glycosuria cannot be constantly demonstrated in patients with mild diabetes. In them glycosuria was found most frequently to follow the ingestion of certain foodstuffs, notably those that contain

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