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THE TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH SULFANILAMIDE:  REVIEW OF THE LITERATURE AND REPORT OF SIX ADDITIONAL CASES

BARBARA A. HEWELL, M.D.; A. GRAEME MITCHELL, M.D.
JAMA. 1939;112(11):1033-1037. doi:10.1001/jama.1939.02800110013003.
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In a review of the literature to the year 1927 the Goldsteins1 collected 150 authentic recoveries from pneumococcic meningitis and there are listed in the Quarterly Cumulative Index Medicus approximately thirty additional recoveries during the years 1927 to 1937. Most of these favorable outcomes have been attributed to spinal drainage and the administration of antipneumococcus serum or ethylhydrocupreine (optochin), but in general results with these therapeutic measures have been unsuccessful.

In the ten years preceding 1937 there were in the Children's Hospital of Cincinnati and in the pediatric service of the Cincinnati General Hospital twenty-three children suffering from pneumococcic meningitis, the mortality in this group being 100 per cent. Since the use of sulfanilamide three patients with the condition have recovered of a total of six treated. The histories of these six patients are summarized.

In table 1 are listed thirty cases of recovery from pneumococcic meningitis in which

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