Other Articles |

Experimentelle Undersøgelser over en transplantabel Leukose hos hvide Mus

JAMA. 1936;107(9):740. doi:10.1001/jama.1936.02770350108037.
Text Size: A A A
Published online


This doctorate thesis deals with the details of experiments on a transmissible leukosis in white mice, starting in a spontaneous instance. Successful transmission was obtained by subcutaneous or intravenous injection of leukosis cells in mice after roentgenization or injection of trypan blue. The peculiar cells were round and of varying size, a narrow rim of basophilic, nongranular cytoplasm enclosing a round or curved nucleus with a fine chromatin network and from two to five nuclei. These cells occurred in varying numbers in the blood as well as in local growths and infiltrations; there also developed myeloid hyperplasia in the marrow and spleen. Comparing this instance with previously described forms of transmissible mammalian leukosis, it appears that Korteweg observed a similar variety in 1929. These two instances are peculiar mainly in that a sudden neutrophil leukocytosis developed before the appearance in the blood of the characteristic cells. As in other forms,


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.