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Yandell Henderson, Ph.D.
JAMA. 1936;107(9):731-732. doi:10.1001/jama.1936.02770350099025.
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To the Editor:—  In The Journal, July 25, pages 267-269, in an article entitled "Hyperventilation in Abdominal Surgery," Dr. T. J. Ryan concludes that "carbon dioxide is of no value in the prevention of postoperative pneumonia."This conclusion is drawn from a group of 135 cases in which, at the close of abdominal operations, carbon dioxide was administered only once, for about three minutes, and a control group of 276 in which carbon dioxide was not administered.The morbidity is reported as 2.2 per cent for those who received the inhalation and 1.4 per cent for those who did not, and the mortality as 0.74 per cent for those treated and 0.36 per cent for those who were not. Obviously, if these figures are significant they indicate, not merely that carbon dioxide is without value in the prevention of postoperative pneumonia, but rather that this treatment tends to increase the


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