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JAMA. 1936;106(22):1875-1879. doi:10.1001/jama.1936.02770220011003.
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In 1913 Durand, Nicolas and Favre1 differentiated from inguinal adenitis due to chancroid, syphilis and tuberculosis a new venereal disease, which they called subacute inguinal lymphogranulomatosis and which they established as a venereal disease entity. This disease has been variously referred to in the literature as a climatic bubo, tropical bubo, nonvenereal bubo, subacute inguinal periadenitis, fourth venereal disease, strumous bubo of the groin, nontuberculous lymphadenitis, subacute lymphadenitis, malady Nicolas-Favre, hypertrophic bubo and lymphopathia venereum.

The primary lesion on the glans penis, in the vagina or elsewhere may be trivial and evanescent and may entirely escape notice. During an incubation period of from ten to thirty days2 inguinal adenitis may develop, and this may result in suppuration. In 1925 Frei3 announced an intradermal skin test, now known as the Frei test, which is characterized by an intradermal nodule appearing from thirty-six to seventy-two hours after injection into


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