We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |


Géza de Takáts, M.D.
JAMA. 1936;106(12):1003-1005. doi:10.1001/jama.1936.92770120001011.
Text Size: A A A
Published online


Papaverine, an alkaloid of the opium group, was first advocated for the relief of smooth muscle spasm by Professor Pal1 of Vienna. On the basis of clinical observations backed up by animal experiments, he stated that the drug relaxes smooth muscle without paralyzing it and recommended it in hypertension, in angina pectoris and for the abortion of uremic crises. A comprehensive pharmacologic study of this drug was given by Macht.2 Summing up the circulatory effects of papaverine, he noted a fall in blood pressure, which was due partly to the effect on the brain but chiefly to peripheral action, as it produced a marked vasodilatation especially of the peripheral and splanchnic arteries. The drug increased coronary circulation, slowed the heart and at the same time increased the strength of contraction. As to its effect on respiration, papaverine dilated the bronchi and diminished the rate of respiration but increased the volume output


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.