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Shields Warren, M.D.; Howard F. Root, M.D.; Elliott P. Joslin, M.D.
JAMA. 1935;105(18):1452. doi:10.1001/jama.1935.02760440061026.
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To the Editor:—  While a letter is too brief a vehicle for the discussion of so disputed a point as the etiology of arteriosclerosis, some statements in the communication of Dr. Eli Moschcowitz regarding diabetes and arteriosclerosis call for a reply. Few would subscribe to the belief that diabetes mellitus alone is a cause of arteriosclerosis, but the evidence is strong that the metabolic disturbances occurring in the course of diabetes are important factors in the development of arteriosclerosis of the atherosclerotic type.With two statements particularly of Dr. Moschcowitz we take issue: 1. "To my mind all evidence seems to show that arteriosclerosis is the cause of diabetes rather than the reverse." 2. "When diabetes occurs in arteriosclerosis, the inference is that the capillaries of the islands of Langerhans are affected."As regards this first point, at least 10 per cent of all cases of diabetes begin in the


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