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ARTICLE |

A HEMOLYTIC BLOOD TRANSFUSION REACTION WITH OLIGURIA

H. G. McCANDLESS, M.D.
JAMA. 1935;105(12):952-954. doi:10.1001/jama.1935.02760380028007.
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My purpose in this paper is to present a case in which recovery followed a hemolytic blood transfusion reaction with suppression of urine.

In 1931 Bordley1 presented a review of the literature and a report of cases of hemolytic transfusion reactions with oliguria, and he added three more from the records of the Johns Hopkins Hospital. From the study of these seventeen cases, according to Bordley,1 a clinical syndrome that is characteristic of the reaction may be outlined as follows: (a) Immediately after the transfusion there is a sharp febrile reaction, followed frequently by hemoglobinuria and invariably by suppression of urine; (b) there is an interval of several days during which there is symptomatic improvement but continued oliguria, and (c) after that interval the characteristic symptoms (agitation or drowsiness followed by uremia with convulsions and coma) develop rapidly and usually reach their peak eight days after the transfusion.

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