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ARTICLE |

MALIGNANT HYPERPLASIA OF THE LYMPH FOLLICLES OF THE SPLEEN

H. RYERSON DECKER, M.D.; H. G. LITTLE, M.D.
JAMA. 1935;105(12):932-934. doi:10.1001/jama.1935.02760380008002.
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In 1925 Brill, Baehr and Rosenthal1 reported three cases of what they called splenomegalia lymphatica hyperplastica. Their observations and review of the literature led them to believe that there had been reported previously only one other similar case, that of Becker in 1901. Several cases were noted of splenic lymph adenosis in which there was lymphoid hyperplasia confined to the spleen and in which splenectomy had been performed.

In 1927 Dr. R. D. Baker reported a case of splenomegaly with enlargement of the lymph nodes, notably the posterior auricular, occipital and inguinal. Biopsy showed giant lymph follicle hyperplasia. With roentgen treatment the glandular involvement receded, but the red blood cells and the bone marrow were damaged. The man died in 1930 and the case was finally diagnosed as chronic lymphatic leukemia.

It was our good fortune to study and treat a case in 1927 similar in most respects to

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