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La protidémie et la pression osmotique des protides: Recherches expérimentales et applications cliniques

JAMA. 1935;105(11):907. doi:10.1001/jama.1935.02760370063031.
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This monograph briefly discusses the literature on the origin and quantities of different proteins in the blood serum and changes in their concentrations and ratios in experimental and clinical studies. The author prefers the alcohol precipitation of proteins and their estimation by weighing to the refractometer method because the latter method gives too high results in the presence of increased lipins. Furthermore the alcohol method also enables one to estimate total lipins. In addition to total protein, a quantitative estimation of globulins was made. Thus the albumin-globulin ratio was determined in each case. The author stresses the importance of this information concerning the differences in the amounts and ratios in different species and the same species in various diseases. The first half of the monograph describes his experiments on dogs and rabbits. From these studies he concludes that the most probable site of formation of serum proteins is the liver,


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