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Studies on Cell Growth (Part II). The Growth in Vitro of Normal Mouse Cells and of Mouse Cancer Cells (Carcinoma, Sarcoma) in Neutral and Immune Media (Serum Plasma)

JAMA. 1935;105(5):389. doi:10.1001/jama.1935.02760310063035.
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The purpose of this work is to decide the controversy between Lumsden and Ludford. According to Lumsden there are specific anticancer substances formed in animals, which are immunized by inoculation with tumor tissue. The action of these serums is highly specific, according to Lumsden. The specificity against the malignant cells was demonstrated by this author in tissue cultures in which he found that the malignant cells were picked out and rapidly killed and the nonmalignant cells remained more or less undamaged. Ludford, on the other side, came to the conclusion that those cells which were considered by Lumsden to be cancer cells in the tissue cultures were not malignant cells but stroma elements. In order to settle this question Des Ligneris inoculated sheep with tumor material from mouse carcinomas and with normal mouse organs and compared the growth of mouse carcinoma tissue and mouse sarcoma tissue as well as of


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