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August 25, 2010, Vol 304, No. 8 >

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Letters | August 25, 2010

High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women

Maurizio Gallieni, MD
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.1167.
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To the Editor: In their randomized controlled trial, Dr Sanders and colleagues1 hypothesized that an annual high-dose oral cholecalciferol administration would reduce the risk of fractures based on previous results in randomized and observational studies but found an increased risk. Other studies, including a Cochrane review,2 had yielded negative results. The mechanisms underlying increased fracture risk from bolus vitamin D supplementation are uncertain. The effects of treatment on 25-hydroxycholecalciferol 24-hydroxylase and 1-alpha-hydroxylase, renal and extrarenal, could be better interpreted if levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D) were determined in the substudy participants who underwent 25-hydroxycholecalciferol serum level assessment. The relative grade of activity of the 2 enzymes could determine increased, unchanged, or diminished serum levels of 1,25(OH)2D.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

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August 25, 2010
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Jenson C. S. Mak, FRACP, FAFRM(RACP), MBBS
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.1165.
August 25, 2010
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Daniel Prieto-Alhambra, MD; Andrew Judge, PhD; Michael Pazianas, MD
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.1166.
August 25, 2010
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women
Renato Bertini Malgarini, MD; Giuseppe Pimpinella, PhD
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.1168.
August 25, 2010
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women—Reply
Kerrie M. Sanders, PhD; Amanda L. Stuart, BAppSc; Geoffrey C. Nicholson, PhD, FRACP
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.1169.
August 25, 2010
High-Dose Oral Vitamin D Supplementation and Risk of Falls in Older Women—Reply
Bess Dawson-Hughes, MD
JAMA. 2010;304(8):854-857. doi:10.1001/jama.2010.781-a.
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