Author Contributions: Dr M. Bredel had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: M. Bredel.
Acquisition of data: Yadav, Renfrow, Xie, Duran, C. Bredel, Chandler, Chakravarti, Robe, Harsh.
Analysis and interpretation of data: Yadav, Renfrow, Scholtens, Xie, Duran, Vogel, Chandler, Chakravarti, Robe, Das, Scheck, Kessler, Soares, Sikic, M. Bredel.
Drafting of the manuscript: M. Bredel.
Critical revision of the manuscript for important intellectual content: Yadav, Renfrow, Scholtens, Xie, Duran, C. Bredel, Vogel, Chandler, Chakravarti, Robe, Das, Scheck, Kessler, Soares, Sikic, Harsh, M. Bredel.
Statistical analysis: Scholtens, M. Bredel.
Obtained funding: M. Bredel.
Administrative, technical, or material support: Renfrow, Vogel, Chandler, Das, Kessler, Sikic, Harsh.
Study supervision: M. Bredel.
Dr Yadav and Ms Renfrow contributed equally to this article.
Financial Disclosures: None reported.
Funding/Support: This work was supported by the State of Illinois Excellence in Academic Medicine Program (EAM Award 211 to Dr M. Bredel), by NIH/NCI RO1CA108633 and funds from The Ohio State University-James Comprehensive Cancer Center (both to Dr Chakravarti), by RTOG U10CA21661 and by CCOP U10CA37422. The results published here are in part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. Information about TCGA and the investigators and institutions that constitute the TCGA research network can be found at http://cancergenome.nih.gov.
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We thank G. Dimri, PhD, NorthShore University HealthSystem Research Institute, Evanston, Illinois, for donating pIK packaging vector used in cotransfection of human shANXA7 knockdown retroviral construct in a pSM2 vector targeting the 1073-1093 mRNA sequence of ANXA7 and C. Svendsen, University of Wisconsin, Madison, for donating fetal neural stem cells (line Ctx M031) used in the pyrosequencing analysis. Neither of these individuals received any compensation in association with their contribution/gift.