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JAMA. 1932;98(7):557. doi:10.1001/jama.1932.02730330039013.
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In 1930 Dr. D. A. Shamburov1 of the Neuropsychiatric Institute, Moscow, claimed that stock vaccines may be injected with safety into the cerebrospinal fluid and that so injected they exert a favorable influence on certain chronic infections of the central nervous system. More recently two important studies have been made by American investigators2 of the immunophysiology of subarachnoid and nervous tissues having a direct bearing on the feasibility of Shamburov's proposed local vaccination. In his preliminary experimental work on rabbits the Russian investigator showed that by routine subcutaneous or intraperitoneal injections of vaccines the specific antibody titer of the cerebrospinal fluid cannot be raised higher than from 0.125 to 0.25 per cent of the corresponding titer of the blood stream. By injecting the same vaccines by suboccipital puncture into the subdural space, however, he found that the antibody content of the cerebrospinal fluid could be increased to as


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