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September 28, 1946, Vol 132, No. 4 >

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ARTICLE | September 28, 1946

BENADRYL, A CONTRIBUTING CAUSE OF AN ACCIDENT

BENJAMIN J. SLATER, M.D.; NATHAN FRANCIS, M.D.
JAMA. 1946;132(4):212-213. doi:10.1001/jama.1946.02870390028006b.
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While it is recognized that benadryl is a very effective agent in the treatment of urticaria and in the control of pruritus in allergic dermatosis, it exhibits a common side reaction, drowsiness, in more than half of the patients taking it. This drowsiness is usually mild, but some patients report that they slept as long as eighteen hours after taking only 50 mg. of Benadryl. When the dose is reduced to 10 or 20 mg. it is better tolerated and the side reactions, if they occur, are diminished. Levin, using 50 to 100 mg. of benadryl every four to six hours in his series of 400 cases, enumerated twentyfour different side reactions, with drowsiness occurring in 60 per cent of his cases. Waldbott, in his series of 165 cases, and using six doses of 50 mg. each, reported 81 cases cf drowsiness. Schwartz reported 20 cases of drowsiness in his

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