The efficacy of replacement therapy in cases of Addison's disease by the injection of suitably prepared extracts of the suprarenal cortex, freed as far as possible from the epinephrine liberated by the medulla of the gland, has apparently been established. Credit is due to several investigators, notably Swingle and his co-workers at Princeton University and Hartman and his collaborators at Buffalo, for their important contributions. The demonstrations have gone beyond the stage of laboratory tests; they have evinced a clinical usefulness in the human organism. In an elaborate review of the experiences on patients, Rowntree1 of the
Mayo Clinic stated without hesitation and after an extensive experience and a long interest in the subject that the cortical hormone is considered by all his co-workers as the most effective remedy in the management of Addison's disease.
As in the case of several hormones, notably epinephrine and insulin, oral administration seems