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Leland W. Parr, Ph.D.; Harald Krischner, M.D.
JAMA. 1932;98(1):47. doi:10.1001/jama.1932.27320270003012a.
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Nearly ten years ago, Levine and Mabee1 called attention to the fact that the use of a type O (Jansky I) subject as a universal donor was not always safe. They presented what was probably the first recognized American case of death from such usage. Another case was presented somewhat later by Freeman and Whitehouse,2 who discussed the problem under the title "The Dangerous Universal Donor." It had been assumed previously that a so-called universal donor was safe because his corpuscles, without agglutinogens, would not be injured when introduced into the circulation of any blood type. Further, it was thought that his serum would ordinarily not work much harm in the recipient's body because it was believed that its titer was low and that if the donated blood was introduced slowly enough the factor of dilution would prevent untoward results. For some time it has been recognized that


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