Pulmonary Hypertrophic Osteoarthropathy

Meyer Alpert, M.D.
JAMA. 1962;180(1):88. doi:10.1001/jama.1962.03050140090031.
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To the Editor:—  In the Dec. 9 issue of The Journal (178:977), there was an interesting article entitled "Pulmonary Hypertrophic Osteoarthropathy" by Drs. Holling and Brodey. In discussing the differential diagnosis, however, the authors made the following incorrect statement, "The fact that idiopathic osteoarthropathy has so far been reported only in unmarried adult males raises the possibility of an associated abnormality of sexual differentiation."While it is true that most of these patients have been males, one female was well documented by Weens (Radiology45:27, 1945). In addition, Oehme noted that his patient's sister was said to be similarly affected (Deutsch Med Wschr45:207, 1919). A third example of this disorder in a female was published by Camp, but the diagnosis is open to question (Radiology50:581, 1948). A fertile, married male patient has been reported by Logue (US Armed Forces Med J4:1627, 1953).


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