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ARTICLE |

Rhodotorula Fungemia Complicating Staphylococcal Endocarditis

Palmer F. Shelburne, M.D.; Robert J. Carey, M.D.
JAMA. 1962;180(1):38-42. doi:10.1001/jama.1962.03050140040009.
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A 56-year-old man with diabetes and staphylococcal endocarditis received intermittent, brief courses of broad-spectrum antibiotics. Fungal superinfection with Rhodotorula resulted. Rhodotorula was cultured repeatedly from the blood and urine during a period of high fever, while the patient was on adequate antibiotic therapy for staphylococcus. During and after treatment with amphotericin B and massive doses of penicillin, repeated blood cultures were sterile, and the patient recovered from this infection and superinfection. Amphotericin B was given intravenously in gradually increasing amounts until a daily dosage of 1.0 mg. per kilogram was achieved for 3 weeks. One can only speculate whether the fungus actually invaded the heart valves, but therapy was continued for this period because of this possibility. Fourteen months after discharge from the hospital, the patient was well except for a residual right hemiparesis.

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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