0
ARTICLE |

EXPERIMENTAL STUDY OF EARLY SYPHILIS WITH NONSPECIFIC THERAPIES

MARTIN F. ENGMAN, M.D.; L. H. JORSTAD, M.D.; M. F. ENGMAN Jr., M.D.
JAMA. 1931;97(21):1503-1506. doi:10.1001/jama.1931.02730210001001.
Text Size: A A A
Published online

It has been known for a number of years that patients with syphilis, particularly those with neurosyphilis, are favorably affected by the production of a rise in body temperature. Probably the earliest investigators to use nonspecific protein therapy in syphilis were Engman and McGarry,1 who in 1916 treated a few cases of generalized early syphilis with typhoid vaccine intravenously. They noted a moderate improvement in the eruption. One conception has been that the heat alone was the main factor in producing the beneficial effect.

Cady, Engman and Elle2 recently inoculated albino rats with Trypanosoma brucei and subjected them to various degrees of heat. Briefly, the method was as follows: A Victor variofrequency diathermy apparatus was used. The rats were placed in a high frequency induction field for a period of time varying from fifteen to forty-five minutes. The body temperature (rectal) was raised from 1 to 3 degrees

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();