Sleep and Quality of Life in Clinical Medicine encompasses 53 chapters closely looking at sleep disturbances induced by specific sleep disorders such as sleep apnea, narcolepsy, restless legs syndrome, and non–rapid eye movement sleep parasomnias (sleep terrors, sleepwalking). This edition also reviews sleep disturbances associated with age-specific physiologic conditions such as pregnancy and sleep disturbances secondary to other medical conditions. This last category evaluates the quality of sleep and quality of life in individuals experiencing pain of various causes such as obesity; gastroesophageal reflux disease; malignancies, especially of the head and neck; human immunodeficiency virus infection; and other diseases of various organs. Impairment of the nervous system is heavily discussed in this edition, with a focus on Alzheimer disease, Parkinson syndrome, multiple sclerosis, neuromuscular disorders, stroke, headache, brain trauma, and multiple psychiatric syndromes ranging from depression to anxiety, from autism to schizophrenia. On the contrary, only 1 chapter is dedicated to sleep and cardiovascular disease.