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Studies Examine Fetal Surgery Trade-offs, Drug Interactions, and Uterine Rupture

Bridget M. Kuehn
JAMA. 2012;307(12):1239-1241. doi:10.1001/jama.2012.315.
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As imaging technologies make it easier to identify congenital abnormalities that might be treated through fetal surgery, clinicians and parents face difficult choices about whether to pursue such innovative treatment or to plan for corrective procedures after birth. As the Agency for Healthcare Research and Quality noted earlier this year, so far there are limited data to guide such choices (http://tinyurl.com/6o7zoa3).

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In utero surgery to treat myelomeningocele, a protrusion of spinal cord through an opening in the spine, may be as cost-effective as surgery performed after delivery.

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Blood levels of 17-α-hydroxyprogesterone caproate, a drug used to prevent recurrent preterm birth, may be reduced when a patient is also taking certain other drugs.



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