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March 21, 2012, Vol 307, No. 11 >

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Letters | March 21, 2012

Urinary Sodium Excretion and Cardiovascular Events

Samuel Mann, MD
JAMA. 2012;307(11):1138-1139. doi:10.1001/jama.2012.326.
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To the Editor: Dr O’Donnell and colleagues, in their study on urinary sodium excretion and risk of cardiovascular events,1 reached the counterintuitive conclusion that sodium restriction increased the risk of cardiovascular events, which runs counter to the consistent evidence that, in individuals with hypertension, decreased sodium intake reduces blood pressure and improves the effectiveness of treatment with antihypertensive agents.2- 4

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March 21, 2007
Treatment of Men With Lower Urinary Tract Symptoms and Overactive Bladder
JAMA. 2007;297(11):1191-1193. doi:10.1001/jama.297.11.1192-a.
March 21, 2012
Urinary Sodium Excretion and Cardiovascular Events—Reply
Martin J. O’Donnell, MB, PhD; Roland E. Schmieder, MD; Salim Yusuf, DPhil, FRCPC, FRSC
JAMA. 2012;307(11):1138-1139. doi:10.1001/jama.2012.327.
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